RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction
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چکیده
منابع مشابه
RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction
AIMS Retinoic acid receptor-related orphan nuclear receptor γt (RORγt) is a transcriptional factor responsible for IL-17-producing T-cell differentiation. Although it was demonstrated that RORγt plays essential roles in the onset of autoimmune myocarditis, pathophysiological significance of RORγt in cardiac remodeling after myocardial infarction (MI) remains to be fully elucidated. METHODS AN...
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Cardiac fibrosis, which occurs mainly because of increased collagen formation by activated cardiac fibroblasts (myofibroblasts), impairs cardiac function, metabolism, and electric coupling of myocardium, resulting in various cardiac diseases, such as heart failure, arrhythmias, and sudden cardiac death. Therefore, prevention of excessive cardiac fibrosis is important for the treatment of these ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0183584